Novel Synthesis of Non-steroidal Anti-inflammatory Drugs by Electrocatalytic Hydrogenation

Non-steroidal , anti-i nfl ammatory drugs (NSAIDs) are a class of medications that possess analges ic and anti-pyretic activit ies 1-5. These are used for reducing fever and inflammation in various muscui os keleta di sorders, menstrual cramps , and body pains 612. NSAIDs are perhaps the commonl y used new group of medications avai lable today, whi ch are frequentl y used, domesticall y and in hea lthcare faciliti es for diversified medica l di sorders. Conventional synthes is of non-steroidal , antiinfl ammatory drugs, like proti zinic acid, benoxaprofen, carprofen, and pranoprofen has already been reported 1.\-16 But, formati on of hazardous chemica ls , like cyanides, low yie lds due to high temperatures and high stereoselectivity, makes thi s method ine ffi c ient. Hence, attempts were focused towards electrochemical approach of these drugs.